Aim: The aim of the present work is to evaluate the clinical and biological effects of Platelet Rich Fibrin (P.R.F.)
in support of implant prosthetic treatments performed on 28 patients.

Materials and Methods: The
Authors studied a sample of 28 patients and decided to divide them into two
groups (A and B) and performed two different implant prosthetic protocols.
The patients included in group A (14 pt) were treated with the traditional
surgical implant protocol while, for the patients of group B, we employed a
surgical implant treatment together with the use of P.R.F. When the Authors
recorded the case history, no patient reported a significant pathological

In all patients of all groups, we achieved a satisfactory osseointegration
and a very good healing of bones and tissues. The substantial difference arises
from the tissue healing time of patients belonging to group B.
These patients, in fact, present a faster cicatrization compared to patients
that were not treated with P.R.F. in support of the implant surgical treatment.
Discussion and conclusions PRF (Platelet-Rich Fibrin) is an autologous fibrin
matrix rich in platelets and growth factors, obtained through a simple blood
sampling and performed during surgery.

PRF can also be considered an
immune and platelet concentrate, and it contains, in the shape of an autologous
fibrin membrane, all the elements favoring cicatrization and immune response
contained in a 10ml blood test tube. The P.R.F. placed on the surgical area is
able to provide many benefits:

a) It favors cicatrization,
angiogenesis and migration of endothelial cells;
b) Immunoregulation of the surgical site, due to the strong presence of
leukocytes activated during centrifugation of the blood sample and to the
presence of cytokines incorporated into the fibrin matrix;
c) Stem cells mobilization through the fibrin;
d) Fibroblast proliferation (+ 29% compared to the controls that were not
treated with P.R.F.) and better quality of elastic fibers; e) Osteoblast
proliferation (+124% compared to the controls that were not treated with P.R.F.).

In the light of this, the
Authors can certainly tell that there are many advantages in using P.R.F. in
support of the implant prosthetic therapy. In particular, the results of the
present study confirm that patients belonging to group B, treated with this
procedure, developed a faster tissue healing and a better quality of life.

F. Inchingolo 1-4, V.
Picciariello1, A. Fioriello 1, A. Palladino 1, M. Tatullo 2, M. Marrelli 4 ,
A.M. Inchingolo 3, F. Carbotti 1, A.D. Inchingolo1,  G. Dipalma1-4
1 Department of Odontostomatology and Surgery, University of Bari, Bari, Italy
2 Private Doctor in Dental Sciences 3 Department of  Odontostomatology and
Surgery, University of  Milano, Milano, Italy  4  Department of  Maxillofacial
Surgery, Calabrodental Srl, Crotone, Italy